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Updated: Aug 7, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
[Wilson's principles--a base of modern teratology]
Franciszek Burdan1, Artur Bełzek, Justyna Szumiło
1Akademia Medyczna w Lublinie, Pracownia Teratologii Doświadczalnej Katedry i Zakładu Anatomii Prawidłowej Człowieka. fb3@wp.pl
Abstract:
Wilson's principles were formulated after thalidomide tragedy. They become a fundamental for teratological studies with drugs and other factors that may disturb fetal development. It is postulated that susceptibility to teratogen depends on the genotype and developmental stage of the conceptus. Teratogenic agents act in specific manner on developing cells and tissues. The exposition depends on the agent's nature and availability. Manifestations of deviant development depends on the dosage and exposure frequency. In case of abnormal development the final manifestations include death of embryo or fetus, malformation, growth retardation and functional disorder.
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