Related Experiment Video
Updated: Aug 7, 2026
10:03
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Aspirin failure course during exercise and its connection with soluble CD40L
Wiktor Kuliczkowski1, Malgorzata Kobusiak-Prokopowicz, Iwona Prajs
1Department of Cardiology, Wroclaw Medical University, Pasteur 4 Street, 50-367 Wroclaw, Poland. wiktor6@wp.pl
Thrombosis Research
|June 20, 2006
Summary
Aspirin resistance affects 37% of patients, with exercise increasing its occurrence. Higher soluble CD40L (sCD40L) levels are linked to aspirin resistance, especially during physical activity.
Area of Science:
- Cardiology
- Immunology
- Pharmacology
Background:
- Aspirin resistance is a significant clinical issue, particularly in patients with atherosclerosis.
- Exercise can precipitate or exacerbate aspirin resistance.
- The CD40-CD40L pathway involving platelets is implicated in aspirin resistance and inflammation.
Purpose of the Study:
- To determine the frequency of exercise-induced aspirin resistance.
- To investigate the role of soluble CD40L (sCD40L) in aspirin resistance.
- To assess the impact of exercise on sCD40L levels and platelet aggregation.
Main Methods:
- Study included 40 coronary artery disease patients and 10 controls on 75 mg aspirin daily.
- Treadmill testing was performed with blood collection for sCD40L and platelet aggregation measurements.
- Aspirin resistance defined as maximal platelet aggregation exceeding 70% with ADP or collagen.
Main Results:
- 37% of patients exhibited aspirin resistance at rest.
- Aspirin-resistant patients showed significantly higher sCD40L levels both at rest and during exercise.
- Exercise induced aspirin resistance in 12% of patients, correlating with increased sCD40L.
Conclusions:
- Aspirin resistance is prevalent (37%) in patients with coronary artery disease on daily aspirin.
- Exercise exacerbates platelet aggregation in aspirin-resistant individuals.
- Elevated sCD40L levels are associated with both resting and exercise-induced aspirin resistance.
Related Concept Videos
01:20Exercise and Cardiovascular Response
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
01:30Peripheral Artery Disease I: Introduction
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
01:27Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
01:30Coronary Artery Disease I: Introduction
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
01:26Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...