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Updated: Aug 7, 2026
Intracerebroventricular Injection of Amyloid-β Peptides in Normal Mice to Acutely Induce Alzheimer-like Cognitive Deficits
Published on: March 16, 2016
Changes of the cortex proteome and Apolipoprotein E in transgenic mouse models of Alzheimer's Disease
O Carrette1, J A Burgess, P R Burkhard
1Neuroproteomics Group, Department of Structural Biology and Bioinformatics, Geneva University, Faculty of Medicine, Geneva, Switzerland. Odile.Carrette@medecine.unige.ch
Abstract:
Transgenic mice carrying human Amyloid Precursor Protein mutations present amyloid plaque deposition in the brain upon aging. In this study, we characterized the changes of cortex proteome and endogenous Apolipoprotein E in these mice. Differential analysis of two-dimensional electrophoresis images revealed spots altered upon aging, transgene addition and plaque deposition. Alpha-synuclein and cytochrome oxidase polypeptide Va were up-regulated in transgenic mice. Upon aging, expression of ATP synthase alpha, alpha enolase, UMP-CMP kinase, and dihydropyrimidinase like-2 protein was modified. These proteins and their modification probably play a role in the amyloid aggregate formation in these mice.
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