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Updated: Aug 7, 2026

Permanent Cerebral Vessel Occlusion via Double Ligature and Transection
Published on: July 21, 2013
Chronic total coronary occlusions
1Cardiology Specialists of North Carolina, 3866 Cedarfield Place Court, Winston-Salem, NC 27106, USA. GBraden@triad.rr.com
Insights
Newer technologies have improved the success of opening chronic total coronary occlusions (CTO). This has increased the demand for these procedures, offering benefits like angina relief and improved survival.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
Background:
- Chronic total coronary occlusions (CTO) affect up to one-third of patients undergoing coronary angiography.
- Indications for CTO intervention include angina relief, improved cardiac function, reduced need for bypass surgery, and enhanced long-term survival.
Purpose of the Study:
- To review advancements in interventional cardiology for treating CTOs.
- To highlight the impact of new technologies on CTO recanalization and patency.
Main Methods:
- Review of recent technological advancements in CTO crossing techniques (wire-based and non-wire-based).
- Evaluation of the role of drug-eluting stents in maintaining long-term patency of treated CTOs.
Main Results:
- Novel technologies have significantly improved the ability to cross previously uncrossable CTO lesions.
- Improved acute success rates for CTO recanalization have been achieved.
- Drug-eluting stents have markedly increased the long-term patency of complex CTO lesions.
Conclusions:
- Advancements in interventional techniques and devices have made CTO treatment more feasible and effective.
- The increased success and improved outcomes for CTO interventions are driving greater clinical demand.
Abstract:
Chronic total coronary occlusions (CTO) occur in up to one-third of patients undergoing coronary angiography. Indications for opening CTOs include relief of angina, improving left ventricular function, decreasing the need for coronary artery bypass surgery, and improved long-term survival. Newer technology, wire-based and non-wired-based, has improved the ability to cross these previously uncrossable lesions, thereby improving the acute success rates of opening these lesions. Also, the advent of drug-eluting stents has markedly increased the long-term patency of these complex lesions. Therefore, the clinical demand for opening these chronically occluded arteries has increased.
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