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Updated: Aug 7, 2026

A Minimally Invasive Model to Analyze Endochondral Fracture Healing in Mice Under Standardized Biomechanical Conditions
Published on: March 22, 2018
[Stability of the miniscrew implant during healing period]
Jing Wu1, Yu-xing Bai, Bang-kang Wang
1Department of Orthodontics, Faculty of Stomatology, Capital University of Medical Sciences, Beijing 100050, China.
Objective:
To evaluate the stability of mini-screw implant during different healing periods in the unloaded conditions.
Methods:
Sixty titanium mini-screws were used in this study. A total of 10 New Zealand white rabbits were randomly divided into 5 groups according to different healing periods. The stability was evaluated biomechanically at different time points. One-way ANOVA and correlation analyses were used.
Results:
(1) After 4 weeks and 8 weeks of healing, maximal pull-out loads were (179.68 +/- 24.65) N and (212.06 +/- 42.51) N, respectively. The maximal torques were (0.47 +/- 0.13) N.m and (0.61 +/- 0.16) N.m, respectively. (2) Significant difference in maximal torque was found between 4 week and 8 week healing groups. (3) Both reverse torque and pull-out load significantly correlated with healing time.
Conclusions:
Fourth-week is a critical time point in the progress of osseointegration. Within 8 weeks of healing process, the stability of implant was significantly correlated with healing time.
