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Screening the receptorome.

Wesley K Kroeze1, Bryan L Roth

  • 1Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, OH 44106, USA.

Journal of Psychopharmacology (Oxford, England)
|June 21, 2006
PubMed
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The receptorome, encompassing drug targets like G protein-coupled receptors, is expanding. Drug discovery may shift towards multi-target approaches, utilizing computational screening and public databases.

Area of Science:

  • Pharmacology
  • Genomics
  • Drug Discovery

Background:

  • The 'receptorome' refers to receptors, ion channels, and transporters in the human genome with therapeutic potential.
  • These proteins constitute a significant portion of the human genome, notably G protein-coupled receptors, which are targets for numerous drugs.

Purpose of the Study:

  • To review recent advancements in understanding the receptorome and its implications for drug discovery.
  • To explore evolving concepts in drug development, including multi-target screening and computational approaches.

Main Methods:

  • Review of current literature on receptorome research.
  • Discussion of computational screening techniques.
  • Analysis of public domain databases for drug discovery.

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Main Results:

  • The receptorome represents a vast landscape of potential drug targets.
  • Drug discovery paradigms are shifting from single-target selectivity to multi-target strategies.
  • Potential side effects can be proactively addressed through multi-target screening.

Conclusions:

  • The receptorome offers extensive opportunities for novel therapeutic interventions.
  • Computational tools and accessible databases are crucial for modern drug discovery.
  • Future drug development may prioritize broader target engagement for efficacy and safety.