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Related Experiment Videos

Restricted expression of Fgf16 within the developing chick inner ear.

Susan C Chapman1, Qin Cai, Steven B Bleyl

  • 1University of Utah, School of Medicine, Department of Neurobiology and Anatomy, and Children's Health Research Center, Salt Lake City, Utah 84132, USA. susan.chapman@utah.edu

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|June 21, 2006
PubMed
Summary

Fibroblast growth factor 16 (Fgf16) is crucial for inner ear development. Its expression pattern in chick embryos suggests a role in sensory patch formation alongside bone morphogenetic protein signaling.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Fibroblast growth factor (FGF) signaling is vital for the induction and patterning of the developing inner ear.
  • Understanding the specific roles of FGF family members, like Fgf16, is essential for elucidating inner ear development.

Purpose of the Study:

  • To clone the chick ortholog of Fgf16.
  • To analyze the expression pattern of Fgf16 in early chick embryos.
  • To investigate the potential role of Fgf16 in inner ear patterning.

Main Methods:

  • Cloning of the chick Fgf16 gene.
  • Whole-mount in situ hybridization to determine Fgf16 expression patterns.
  • Comparison of Fgf16 expression with known developmental markers like Bmp4 and PDGFA.

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Main Results:

  • Chick Fgf16 was successfully cloned.
  • Fgf16 expression was observed in the otic placode and developing inner ear throughout development.
  • By the closed otocyst stage, Fgf16 expression localized to anterior and posterior domains, overlapping with Bmp4 and PDGFA expression.

Conclusions:

  • The restricted expression pattern of Fgf16 indicates its involvement in the patterning of the developing inner ear.
  • FGF signaling, in conjunction with BMP signaling, likely plays a significant role in the formation of sensory cristae.