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[Childhood upper respiratory infection caused by Mycoplasma pneumoniae]
Ding Lu1, Shi-Qiang Liu, Li-Bao Zhuang
1Department of Pediatrics, Shanghai No.8 People's Hospital, Shanghai 200233, China. luding146@sina.com
Objective:
This study was designed to investigate the prevalence, clinical characteristics and outcome of upper respiratory infection (URI) caused by Mycoplasma pneumoniae (MP) in children.
Methods:
Pharyngeal cultures for MP antibody were performed in 960 children with acute URI. The samples were randomly collected from the outpatient room or emergency room (Observed group). Of the Observed group, there were 232 cases under 1 year of age, and the remainder, were between 1-12 years old. The samples from 100 healthy children aged from 6 months to 12 years were used as the Control group. The prevalence of MP infection between the two groups was compared. The clinical manifestations and the outcome between the patients with MP positive and negative were compared.
Results:
MP antibody was positive in 31.7% (304/960) of the Observed group but only 9.0% (9/100) in the Control group (P < 0.05). The URI patients under 1 year of age had a lower positive rate of MP than those over 1 year old (P < 0.05). Coughs and tonsillitis were more common (P < 0.05), but catarrh, gastroenteritic symptoms, herpes, and tetter were rare (P < 0.01) in URI patients with MP positive compared with those with MP negative. Pneumonia developed in 14.8% of the patients with MP positive but only 7.0% in those with MP negative (P < 0.01).
Conclusions:
MP is one of the main pathogens of acute URI in children. Acute pharyngotonsillitis symptoms are predominately presented in children with MP infection. MP infection was commonly seen in children over 1 year old and they are prone to develop pneumonia.
Insights
Mycoplasma pneumoniae (MP) is a common cause of upper respiratory infections (URI) in children, particularly those over one year old. MP-positive URI cases often present with cough and tonsillitis and have a higher risk of developing pneumonia.
Area of Science:
- Pediatric infectious diseases
- Microbiology
- Respiratory medicine
Context:
- Acute upper respiratory infections (URI) are common in children.
- Mycoplasma pneumoniae (MP) is a significant pathogen contributing to URIs.
- Understanding MP prevalence and clinical impact in children is crucial for effective management.
Purpose:
- To determine the prevalence of Mycoplasma pneumoniae (MP) in children with acute URI.
- To describe the clinical characteristics and outcomes associated with MP infection in pediatric URI.
- To compare MP prevalence and outcomes between different age groups and with non-infected controls.
Summary:
- MP antibody was detected in 31.7% of children with acute URI versus 9.0% in controls.
- MP infection was more prevalent in children over one year old.
- Symptoms like cough and tonsillitis were more frequent in MP-positive cases, with a higher incidence of pneumonia (14.8% vs 7.0%).
Impact:
- MP is identified as a primary pathogen in pediatric acute URI.
- Pharyngotonsillitis is a predominant symptom of MP infection in children.
- Children over one year old with MP infection face an increased risk of developing pneumonia.
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