Related Experiment Video
Updated: Aug 7, 2026
09:37
Genome Editing and Directed Differentiation of hPSCs for Interrogating Lineage Determinants in Human Pancreatic Development
Published on: March 5, 2017
Psoriasis: the application of genetic technology and mapping
1Division of Dermatology, Department of Internal Medicine, Salt Lake City Veterans Administration Medical Cente, Salt Lake City, Utah, USA.
The Journal of Investigative Dermatology
|November 1, 1990
Summary
Genetic mapping of the human genome using RFLP allows for the placement of genetic diseases. However, psoriasis genetic studies face challenges like heterogeneity and environmental influences.
Area of Science:
- Genetics
- Molecular Biology
- Genomics
Background:
- Recent advancements in molecular genetics have enabled the creation of a human genome map.
- Restriction Fragment Length Polymorphism (RFLP) is a key technology in constructing this map.
- Genetic diseases can be localized on the human genome map if sufficient family data is available.
Purpose of the Study:
- To explore the application of human genome mapping in genetic studies of psoriasis.
- To identify the challenges and complexities in conducting genetic research for psoriasis.
Main Methods:
- Utilizing Restriction Fragment Length Polymorphism (RFLP) for genetic mapping.
- Analyzing family structures to facilitate disease gene localization.
- Investigating genetic disease inheritance patterns.
Main Results:
- Human genome mapping using RFLP is feasible for localizing genetic diseases.
- Psoriasis genetic studies are complicated by disease heterogeneity.
- Environmental factors significantly influence psoriasis gene expression.
- A clear mode of inheritance for psoriasis remains elusive.
Conclusions:
- Human genome mapping provides a framework for genetic disease research.
- Psoriasis genetic studies require careful consideration of heterogeneity and environmental interactions.
- Further research is needed to clarify the genetic basis of psoriasis.
Related Concept Videos
01:29Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
02:46Genetic Screens
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
01:22iPS Cell Differentiation
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
01:21EPS and iPS Cells in Disease Research
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
01:06Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic cells are...
01:29Somatic to iPS Cell Reprogramming
Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...