Related Experiment Video
Updated: Aug 7, 2026
10:31
Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
Lymphocyte chemoattractants in psoriasis and normal skin
R D Camp1, K B Bacon, N J Fincham
1Institute of Dermatology, St. Thomas's Hospital, London, Great Britain.
The Journal of Investigative Dermatology
|November 1, 1990
Summary
Local skin compounds attract lymphocytes, influencing normal trafficking and disease. Researchers identified a novel chemoattractant, plasma-associated lymphocyte chemoattractant (PALC), in normal skin, aiding understanding of skin immunity.
Area of Science:
- Dermatology
- Immunology
- Biochemistry
Background:
- Lymphocyte chemoattractants play a role in skin immune responses.
- Psoriatic lesions show evidence of acidic lipid chemoattractants, like 12[R]-hydroxyeicosatetraenoic acid.
- Lymphocyte attractant activity is present in both normal and psoriatic skin.
Purpose of the Study:
- To review evidence for lymphocyte chemoattractants in psoriatic lesions.
- To investigate water-extractable lymphocyte attractant activity in normal and psoriatic skin.
- To characterize and identify novel lymphocyte chemoattractant compounds in normal skin.
Main Methods:
- Review of scientific literature on psoriatic lesions and chemoattractants.
- Extraction and analysis of water-soluble components from skin samples.
- Biochemical characterization of low molecular weight (<10 kD) skin fractions.
Main Results:
- Acidic lipid chemoattractants, including 12[R]-hydroxyeicosatetraenoic acid, are produced in psoriatic lesions.
- Lymphocyte attractant activity was detected in water extracts of normal and psoriatic stratum corneum.
- A novel, unidentified compound, termed plasma-associated lymphocyte chemoattractant (PALC), was isolated from normal skin.
Conclusions:
- Local production of lymphocyte attractants significantly impacts skin physiology and pathology.
- PALC represents a newly discovered factor involved in regulating lymphocyte trafficking in normal skin.
- Further research into PALC and other skin chemoattractants is crucial for understanding immune cell dynamics in the skin.
Related Concept Videos
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:21Chemotaxis and Direction of Cell Migration
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...