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Related Experiment Videos

Morphine sulfate attenuates hemorrhagic shock-induced hyperpermeability.

Craig Charleston1, Rudolph Puana, Russell K McAllister

  • 1Department of Anesthesiology, Scott and White Clinic and Memorial Hospital, Scott, Sherwood and Brindley Foundation, Texas A&M University System Health Science Center College of Medicine,2401 South 31st St., Temple, Texas 76508, USA.

Anesthesia and Analgesia
|June 23, 2006
PubMed
Summary

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Morphine sulfate, previously thought to worsen inflammation after hemorrhagic shock, actually protects the microvasculature by reducing both increased permeability and leukocyte adherence in rats.

Area of Science:

  • Physiology
  • Pharmacology
  • Immunology

Background:

  • Morphine sulfate is used for hemorrhage control but may increase infection rates by modulating immune cells and histamine release.
  • Histamine release by morphine can increase microvascular permeability, potentially worsening inflammation after hemorrhagic shock.

Purpose of the Study:

  • To investigate the role of morphine sulfate in microvascular permeability and leukocyte adherence following hemorrhagic shock.
  • To determine if morphine sulfate aggravates or protects against inflammatory responses after hemorrhagic shock.

Main Methods:

  • Hemorrhagic shock was induced in rats by reducing mean arterial blood pressure.
  • Mesenteric postcapillary venules were examined for changes in microvascular permeability (albumin extravasation) and leukocyte adherence.

Related Experiment Videos

  • Morphine sulfate was administered prior to the shock period.

    • Main Results:

    • Hemorrhagic shock significantly increased albumin leakage and leukocyte adherence to the venular endothelium.
    • Pre-treatment with morphine sulfate (10 microg/kg) attenuated both the increased microvascular permeability and leukocyte adherence.
    • These effects were statistically significant (P < 0.05).

    Conclusions:

    • Contrary to expectations, morphine sulfate did not aggravate the inflammatory response after hemorrhagic shock.
    • Morphine sulfate demonstrated a protective effect on the microvasculature by reducing hyperpermeability and leukocyte adherence.
    • These findings suggest a potential therapeutic benefit of morphine in managing inflammatory complications post-hemorrhagic shock.