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Family-based association study between G72/G30 genetic polymorphism and schizophrenia
Chen-Jee Hong1, Sheue-Jane Hou, Feng-Chang Yen
1Department of Psychiatry, Taipei Veterans General Hospital, Taiwan.
Neuroreport
|June 23, 2006
Summary
Genetic variations in the G72/G30 gene are linked to schizophrenia. A specific G72/G30 gene variant (rs947267 A/C) is associated with schizophrenia, particularly in males, according to a family-based study.
Area of Science:
- Psychiatric Genetics
- Neuroscience
- Human Genetics
Background:
- Previous case-control studies suggest G72/G30 gene variations are associated with schizophrenia and bipolar disorder.
- The G72/G30 gene is located in a genomic region linked to schizophrenia susceptibility.
- Case-control studies risk confounding from population stratification.
Purpose of the Study:
- To investigate the association between the G72/G30 rs947267 (A/C) polymorphism and schizophrenia using a family-based association study.
- To mitigate potential confounding from population stratification inherent in case-control designs.
- To explore potential sex-specific effects of the G72/G30 gene in schizophrenia.
Main Methods:
- Family-based association study design.
- Utilized transmission disequilibrium analysis.
- Sample comprised 216 Chinese families with affected offspring and parents.
Main Results:
- A significant association was found between the G72/G30 rs947267 polymorphism and schizophrenia (P=0.016).
- The A allele of rs947267 was more commonly transmitted to patients with schizophrenia.
- Sex-stratified analysis revealed significant A allele overtransmission in male probands (P=0.031) but not female probands.
Conclusions:
- The G72/G30 gene may play a role in schizophrenia susceptibility.
- Evidence supports an interaction between the G72/G30 gene and sex in the pathogenesis of schizophrenia.