Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolution of CPV-2 and implication for antigenic/genetic characterization.

Vito Martella1, Nicola Decaro, Canio Buonavoglia

  • 1Department of Animal Health and Well-being, Faculty of Veterinary Medicine, University of Bari, S.p. per Casamassima km 3, 70010, Valenzano, Bari, Italia. v.martella@veterinaria.uniba.it

Virus Genes
|June 23, 2006
PubMed
Summary

Amino acid changes in feline parvovirus (FPV) and canine parvovirus (CPV-2) VP2 protein drive antigenic and biological variations. Ongoing CPV-2 evolution necessitates updated diagnostic assays to detect viral changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating the evolution of the Arctic lineage of canine distemper virus circulating in Italy.

Veterinary research·2026
Same author

Feline bocaparvovirus in domestic cats with gastrointestinal disease.

Veterinary journal (London, England : 1997)·2026
Same author

Detection of bovine coronavirus in myocardial tissue of a naturally infected calf.

One health (Amsterdam, Netherlands)·2026
Same author

Lemon Juice Activity Against Caprine Alphaherpesvirus-1: An In Vitro Study.

Antibiotics (Basel, Switzerland)·2026
Same author

Diagnostic odyssey of a German shepherd dog with disseminated <i>Penicillium labradoris</i> infection: a case report.

Frontiers in veterinary science·2026
Same author

Geospatial insights and artificial intelligence in West Nile virus disease Epidemiology: The Italy case study.

Public health·2026

Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Background:

  • Feline parvovirus (FPV) and canine parvovirus type 2 (CPV-2) are closely related viruses with significant antigenic differences.
  • The viral protein VP2 is a key determinant of antigenic and biological properties in parvoviruses.

Purpose of the Study:

  • To investigate the amino acid differences in VP2 that contribute to antigenic and biological variations among FPV, CPV-2, and its variants (2a, 2b).
  • To assess the ongoing evolution of CPV-2 and its implications for diagnostic strategies.

Main Methods:

  • Comparative analysis of amino acid sequences of VP2 from FPV, CPV-2, and CPV-2 variants.
  • Examination of amino acid changes within critical antigenic regions of the CPV-2 capsid.

Related Experiment Videos

Main Results:

  • Specific amino acid substitutions in VP2 correlate with distinct antigenic profiles and biological behaviors of FPV and CPV-2 strains.
  • Evidence indicates continuous evolution of CPV-2, with new amino acid alterations emerging in key antigenic sites.
  • These alterations modify the virus's antigenic characteristics.

Conclusions:

  • Amino acid variations in VP2 are crucial for the antigenic and biological divergence of FPV and CPV-2.
  • The ongoing evolution of CPV-2 poses challenges for current diagnostic methods.
  • There is a pressing need to update and implement improved diagnostic assays to accurately detect evolving CPV-2 strains.