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Jugular foramen chordoid meningioma
Hidehiro Takei1, Andreana Rivera, Hiroyoshi Suzuki
1Department of Pathology, Baylor College of Medicine, Houston, Texas 77030-3498, USA. htakei@bcm.tmc.edu
Pathology International
|June 24, 2006
Summary
This is the first reported case of chordoid meningioma (CM) in the jugular foramen. Accurate diagnosis requires careful histological and immunohistochemical analysis to differentiate it from other tumors.
Area of Science:
- Neuro-oncology
- Pathology
Background:
- Chordoid meningioma (CM) is a rare histological variant of meningioma, often classified as atypical based on morphology alone.
- Jugular foramen tumors can present with diverse symptoms and challenging differential diagnoses.
Observation:
- A 45-year-old woman presented with progressive right hearing loss.
- MRI revealed a large, dumbbell-shaped mass in the right jugular foramen with extension to the cerebellopontine angle and carotid space.
- Intraoperative findings indicated involvement of cranial nerves IX and X.
Findings:
- Microscopic examination showed tumor cells in cords and nests within a mucinous background.
- Immunohistochemistry revealed positivity for epithelial membrane antigen and vimentin, with negativity for S-100, cytokeratin, CD34, GFAP, synaptophysin, and chromogranin A.
- The tumor exhibited chordoid histology and an organoid lobular arrangement.
Implications:
- This case highlights the importance of considering CM in the differential diagnosis of jugular foramen tumors.
- Distinguishing CM from chordoma and paraganglioma (glomus jugulare tumor) is crucial and relies on characteristic histology and immunohistochemistry.
- Accurate diagnosis is essential for appropriate management and patient outcomes.
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