[Determination of octafluoropropane content in human albumin micropheres loaded with octafluoropropane]
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
1Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Objective:
To develop a method for determinating the octafluoropropane (OFP) content in human albumin micropheres loaded with OFP.
Methods:
OFP content in the loaded human albumin micropheres was determined by means of gas chromatography coupled with mass spetrum/selected ion monitoring (GC-MS/SIM).
Results:
The calibration curve was linear within the concentration range of 40.92-16,368 nmol/L (R(2)=0.9999). The limit of detection was 8.18 nmol/L, and the recovery rate was (100.98-/+1.4)% (204 nmol/L), (102.63-/+2.29)% (2,046 nmol/L) and (97.5-/+2.2)% (8,184 nmol/L), respectively. The intra-day and inter-day RSDs were 0.6%-2.0% and 0.86%-2.3%, respectively.
Conclusion:
The method of GC-MS/SIM is accurate, sensitive, precise and applicable for OFP determination in the microspheres.
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