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The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
08:53

The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

Angiogenesis in atherogenesis

Joerg Herrmann1, Lilach O Lerman, Debabrata Mukhopadhyay

  • 1Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|June 24, 2006
PubMed

Insights

Atherogenesis, the development of atherosclerotic cardiovascular disease, involves neovascularization. Recent findings highlight the crucial role of angiogenesis in this process, similar to cancer neovessel formation.

Area of Science:

  • Cardiovascular Science
  • Pathobiology
  • Oncology

Background:

  • Atherogenesis is a complex process underlying atherosclerotic cardiovascular disease.
  • It involves distinct stages: initiation, progression, and clinical complication.
  • Neovascularization, particularly angiogenesis, is increasingly recognized as a key factor.

Purpose of the Study:

  • To provide an updated overview of angiogenesis in atherogenesis.
  • To discuss the implications of neovessel formation in cardiovascular disease development.
  • To compare angiogenic processes in atherosclerosis and carcinogenesis.

Main Methods:

  • Literature review and synthesis of recent research findings.
  • Analysis of the role of angiogenesis in the stages of atherogenesis.
  • Comparative analysis of neovascularization in atherosclerosis and cancer.

Main Results:

  • Angiogenesis plays a significant role throughout the atherogenesis process.
  • Neovessel formation contributes to the progression and complication of atherosclerotic lesions.
  • Similarities exist between neovascularization in atherosclerosis and carcinogenesis.

Conclusions:

  • Angiogenesis is a critical component of atherogenesis, influencing disease development.
  • Understanding these angiogenic mechanisms offers potential therapeutic targets.
  • Further research into the parallels between cardiovascular disease and cancer neovascularization is warranted.

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