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Optimized Protocol for Efficient Transfection of Dendritic Cells without Cell Maturation
Published on: July 8, 2011
Optimal control in a model of dendritic cell transfection cancer immunotherapy
Filippo Castiglione1, Benedetto Piccoli
1Istituto Applicazioni del Calcolo (IAC) M. Picone, Consiglio Nazionale delle Ricerche (CNR), Viale del Policlinico, 137-00161, Rome, Italy. f.castiglione@iac.cnr.it
Abstract:
We construct a population dynamics model of the competition among immune system cells and generic tumor cells. Then, we apply the theory of optimal control to find the optimal schedule of injection of autologous dendritic cells used as immunotherapeutic agent. The optimization method works for a general ODE system and can be applied to find the optimal schedule in a variety of medical treatments that have been described by a mathematical model.

