Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone remodeling in post-menopausal osteoporosis.

U H Lerner1

  • 1Department of Oral Cell Biology, Umeå University, Umeå SE-901 87, Sweden. Ulf.Lerner@odont.umu.se

Journal of Dental Research
|June 27, 2006
PubMed
Summary

Sex hormones are crucial for maintaining bone mass by balancing osteoblasts and osteoclasts. Their deficiency increases osteoporosis risk, a growing global health concern.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Osteonecrosis not exclusively confined to the jawbones.

British dental journal·2025
Same author

The PerioGene North Study Uncovers Serum Proteins Related to Periodontitis.

Journal of dental research·2024
Same author

Phytocystatin CsinCPI-2 Reduces Osteoclastogenesis and Alveolar Bone Loss.

Journal of dental research·2021
Same author

High platelet count is associated with low bone mineral density: The MrOS Sweden cohort.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

THE CRUCIAL ROLE OF THE WNT SYSTEM IN BONE REMODELLING.

Acta endocrinologica (Bucharest, Romania : 2005)·2019
Same author

High plasma osteocalcin is associated with low blood haemoglobin in elderly men: the MrOS Sweden Study.

Journal of internal medicine·2016

Area of Science:

  • Skeletal Biology
  • Endocrinology
  • Cellular Mechanisms

Background:

  • Bone mass relies on balanced osteoblast and osteoclast activity within bone multicellular units.
  • Bone remodeling is vital for repair, old bone removal, and mineral homeostasis.
  • Hormones, cytokines, and mechanical loading regulate osteoblast and osteoclast functions.

Purpose of the Study:

  • To review cellular and molecular mechanisms of bone remodeling.
  • To summarize the influence of sex hormones on bone remodeling processes.
  • To provide context for a comparative analysis of osteoporosis and inflammation-induced bone remodeling.

Main Methods:

  • Literature review of cellular and molecular mechanisms.
  • Analysis of the role of sex hormones in bone metabolism.
  • Synthesis of existing research on bone remodeling regulation.

Main Results:

  • Sex hormones, particularly estrogen and testosterone, are critical for maintaining bone mass.
  • Lack of sex hormones leads to reduced bone mass and elevated osteoporosis risk.
  • Dysregulation of bone remodeling contributes to the increasing prevalence of osteoporotic fractures.

Conclusions:

  • Understanding sex hormone influence is key to addressing osteoporosis.
  • Bone remodeling pathways are complex and influenced by multiple factors.
  • Further research is needed to compare different osteoporosis etiologies and their systemic impacts.

Related Experiment Videos