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Updated: Aug 7, 2026
Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
Experimental study of acute organophosphorus compound poisoning in rabbit kidneys by ultrasonic tissue
Jun-Ying Cao1, Bao-Zhen Zhao, Su-Qi Jiang
1Department of Ultrasound, General Military Hospital of Shenyang, 83 Wen-Hua Rd, Shen-He District, Shenyang 110016, China. caojunying@hotmail.com
Objective:
The purpose of this study was to investigate the value of integrated backscatter (IBS) of kidneys in acute organophosphorus compound poisoning in rabbits.
Methods:
Eighteen rabbits were poisoned by dimethyl dichlorovinyl phosphate to establish animal models. Sonographic examinations were performed before (T0) and after (T1-T9) the rabbits were poisoned. The echo and size of kidneys were evaluated by 2-dimensional gray scale sonography. Changes of the renal cortex and medulla were analyzed quantitatively with IBS.
Results:
No change of the cortex echo was found before and after poisoning. A significant change of the volume of kidneys on both sides began at T6 compared with that at T0 (P < .05). A significant change of renal length on both sides began at T7 compared with that at T0 (P < .05). The volume change was earlier than that of length. A significant change in IBS% of the renal cortex began at T5 compared with that at T0 (P < .05), whereas a significant change in IBS% of the renal medulla began at T6 compared with that at T(0) (P < .05). The change in IBS% of the renal cortex was earlier.
Conclusions:
More useful information provided by IBS% has been found in acute organophosphorus compound poisoning in rabbits.
