Related Experiment Video
Updated: Aug 7, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array
Published on: November 15, 2017
Novel design of multicapillary arrays for high-throughput DNA sequencing
Andriy Tsupryk1, Michael Gorbovitski, Evgeni A Kabotyanski
1Electrical and Computer Engineering Department, State University of New York at Stony Brook, Stony Brook, NY, USA. atsupryk@ic.sunysb.edu
Abstract:
A novel approach to design and optimize linear multicapillary arrays (LMCAs) for high-throughput DNA sequencing is proposed. A significant increase in the number of capillary lanes is obtained due to the use of composite insertions alternately placed between working capillaries of the array and a specific combination of refractive indices of the DNA separation matrix, capillary glass, the insertions and a medium which surrounds the capillary array. Theoretical and experimental studies showed that in conjunction with a dual-side laser illumination scheme, the proposed LMCA design allows a simultaneous uniform irradiation of as many as 550 working capillaries.
Related Concept Videos
DNA Microarrays
Next-generation Sequencing
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.

