Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydrophobic hydration in cyclodextrin complexation.

Nicolas Taulier, Tigran V Chalikian

    The Journal of Physical Chemistry. B
    |June 28, 2006
    PubMed
    Summary

    Hydrophobic interactions stabilize the 1-adamantanecarboxylic acid (AD) and beta-cyclodextrin (beta-CD) complex, releasing 20-25 water molecules. This binding involves displacement of water from hydrophobic regions of AD and beta-CD.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reversible & Microbubble Concentration-Dependent Permeabilization of an <i>In Vitro</i> Human Endothelial Barrier to Small Molecules Using Ultrasound: Implications for Neurodegenerative Diseases Therapy.

    Molecular pharmaceutics·2026
    Same author

    Development of acoustic systems for ultrasound attenuation measurement in polydimethylsiloxane.

    Medical engineering & physics·2026
    Same author

    Combined Docetaxel-Loaded Perfluorocarbon Nanodroplets with Ultrasound-Mediated Blood-Brain Barrier Disruption for Effective Glioblastoma Treatment in Mice Model.

    International journal of nanomedicine·2026
    Same author

    Thermodynamic control of gene regulation.

    QRB discovery·2025
    Same author

    Binding of Tetrapentylammonium to a c-MYC G-quadruplex Depicted through NMR and Volumetric Assessment.

    Chemistry (Weinheim an der Bergstrasse, Germany)·2025
    Same author

    Immunomodulatory microbubbles targeting integrin αvβ3 in combination with immunotherapy for the theranostic of anaplastic thyroid cancer in mice.

    Journal of controlled release : official journal of the Controlled Release Society·2025

    Area of Science:

    • Physical Chemistry
    • Supramolecular Chemistry
    • Biophysical Chemistry

    Background:

    • Investigates the molecular interactions between 1-adamantanecarboxylic acid (AD) and beta-cyclodextrin (beta-CD).
    • Utilizes temperature-dependent acoustic and densimetric measurements to analyze binding thermodynamics.
    • Focuses on changes in volume, expansibility, and adiabatic compressibility during complex formation.

    Discussion:

    • Interprets volumetric data in terms of hydration changes upon AD-beta-CD complexation.
    • Estimates the displacement of 20-25 water molecules from hydration shells at 25°C.
    • Attributes water displacement primarily to hydrophobic interactions within AD and beta-CD.

    Key Insights:

    • Hydrophobic interactions are a major driving force for stabilizing the AD-beta-CD complex.
    • The number of released water molecules aligns with structural expectations and osmotic stress data.
    • Confirms that volumetric and osmotic stress methods probe similar hydration layers.

    Outlook:

    • Further investigation into the specific structural arrangements of displaced water molecules.
    • Exploring the role of hydration in other host-guest complexation systems.
    • Potential applications in drug delivery and molecular recognition based on hydrophobic interactions.

    Related Experiment Videos