Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet aggregation in atopic dermatitis.

B Rogala1, J Gumprecht, J Glück

  • 1Department and Clinic of Internal Diseases, Allergology and Clinical Immunology, Silesian University School of Medicine, Katowice, Poland.

Platelets
|June 28, 2006
PubMed
Summary

Platelet aggregation intensity and velocity were similar in atopic dermatitis patients and healthy individuals. This suggests platelet function is not impaired in atopic dermatitis, unlike other allergic inflammatory conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Traumatic right atrial rupture bridge to definitive repair with extra-corporeal life support.

Trauma case reports·2020
Same author

Serum Irisin, Adropin, and Preptin in Obese Patients 6 Months After Bariatric Surgery.

Obesity surgery·2019
Same author

Overweight and obesity may play a role in the pathogenesis of chronic spontaneous urticaria.

Clinical and experimental dermatology·2018
Same author

A case of Good's syndrome diagnosed after more than 20 years since onset of myasthenia in a patient with psoriasis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2016
Same author

Chronic urticaria in myasthenia gravis patients - more than occasional coexistence?

Allergologia et immunopathologia·2013
Same author

Possible contribution of chemokine receptor CCR2 and CCR5 polymorphisms in the pathogenesis of chronic spontaneous autoreactive urticaria.

Allergologia et immunopathologia·2013

Area of Science:

  • Immunology
  • Dermatology
  • Hematology

Background:

  • Platelets are implicated in allergic inflammation.
  • Their role in atopic dermatitis (AD) is not well understood.
  • Research is needed to explore platelet function in AD.

Purpose of the Study:

  • To investigate platelet aggregation intensity and velocity in AD patients.
  • To assess the relationship between platelet aggregation and immunoglobulin E (IgE) levels in AD.
  • To compare platelet function in AD patients versus healthy controls.

Main Methods:

  • Evaluated platelet aggregation using the Born method in a dual-channel aggregometer.
  • Tested aggregation response to adenosine diphosphate (ADP), thrombin, and collagen.
  • Included 12 AD patients and 12 healthy non-atopic individuals.

Related Experiment Videos

Main Results:

  • No significant differences in platelet aggregation intensity or velocity were observed between AD patients and controls.
  • Platelet counts were also comparable between the groups.
  • Results were consistent across all tested exogenous stimulators (ADP, thrombin, collagen).

Conclusions:

  • Platelet aggregation is not impaired in patients with atopic dermatitis.
  • Unlike other atopic diseases, AD does not appear to involve altered platelet function.
  • Further research may clarify the precise role of platelets in AD pathogenesis.