[Echocardiographic analysis in cardiac amyloidosis]
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Updated: Aug 7, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Published on: December 13, 2019
C Hurrel1, S Deriaz-Chessex, G Waeber
1Service de Médecine Interne, Département de Médecine, CHUV, Lausanne.
Insights
Systemic amyloidosis can cause heart failure or arrhythmias. Early echocardiography diagnosis is crucial for managing cardiac amyloidosis before heart failure develops.
Area of Science:
- Cardiology
- Internal Medicine
- Pathology
Background:
- Systemic amyloidosis can affect the heart, leading to heart failure or arrhythmias.
- Cardiac amyloidosis often presents with symptoms refractory to standard treatments.
Observation:
- Two cases of cardiac amyloidosis presenting as treatment-resistant heart failure are described.
- Echocardiography plays a vital role in diagnosing cardiac amyloidosis.
Findings:
- Echocardiography is key for diagnosis and prognosis in cardiac amyloidosis.
- Early detection allows for timely intervention.
Implications:
- Targeted therapies against amyloid fibril generation are most effective before heart failure onset.
- Prompt diagnosis and treatment are essential for improving outcomes in cardiac amyloidosis.
Abstract:
Systemic amyloidosis with cardiac involvement may clinically be suspected in the presence of heart failure or arrhythmia of unknown origin. Herein two cases of cardiac amyloidosis are described with a clinical presentation of heart failure refractory to usual treatment. The key role of echocardiography in the diagnosis and prognosis evaluation of cardiac amyloidosis is discussed. A treatment targeted against the generation of amyloid fibril should ideally be initiated before apparition of heart failure.
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