Related Experiment Videos
Sensitivity of CAPD/IPD peritonitis organisms to ciprofloxacin
G B Pylypchuk1, J Conly, J E Kappel
1Department of Medicine, St. Paul's Hospital, Saskatoon, Sask.
Abstract:
Studies have suggested that oral quinolones may be useful in the treatment of peritonitis in peritoneal dialysis. We undertook a study of organisms causing peritonitis in our IPD and CAPD populations to determine if these organisms would be susceptible in vitro to Cipro. We determined the minimal inhibitory concentrations (MIC) of 62 non-duplicate isolates from episodes of peritonitis to Cipro by standard broth microdilution. Serial dilutions were done with Cipro and MIC50 and MIC90 were determined. The isolates were as follows: S, epidermidis (17), S. aureus (14), coliforms (11), Pseudomonas (8), Enterococci (8), Diphtheroids (4). The MIC50 and MIC90 for each of the isolate groups and overall are shown below.
Insights
This study evaluated common peritonitis-causing bacteria from peritoneal dialysis patients for susceptibility to ciprofloxacin (Cipro). Most isolates showed in vitro susceptibility, suggesting Cipro
Area of Science:
- Nephrology
- Infectious Diseases
- Microbiology
Background:
- Peritonitis is a serious complication in peritoneal dialysis.
- Oral quinolones are being explored for peritonitis treatment.
- Understanding bacterial susceptibility is crucial for effective treatment.
Purpose of the Study:
- To assess the in vitro susceptibility of common peritonitis pathogens to ciprofloxacin.
- To evaluate organisms isolated from continuous ambulatory peritoneal dialysis (CAPD) and intermittent peritoneal dialysis (IPD) populations.
Main Methods:
- Minimal inhibitory concentrations (MICs) of ciprofloxacin were determined for 62 bacterial isolates.
- Standard broth microdilution was used to test susceptibility.
- MIC50 and MIC90 values were calculated for different bacterial groups.
Main Results:
- Common isolates included Staphylococcus epidermidis, Staphylococcus aureus, coliforms, Pseudomonas, Enterococci, and Diphtheroids.
- The study determined MIC50 and MIC90 values for ciprofloxacin against these isolates.
- Detailed MIC data for each group and overall susceptibility were presented.
Conclusions:
- The findings support the potential utility of ciprofloxacin in treating peritonitis in peritoneal dialysis patients.
- In vitro susceptibility data guides empirical antibiotic choices for peritonitis management.
- Further clinical studies may confirm the efficacy of ciprofloxacin for PD-associated peritonitis.