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Updated: Aug 7, 2026
07:39
Assessment of Nerve Injury-Induced Mechanical Hypersensitivity in Rats Using an Orofacial Operant Pain Assay
Published on: July 26, 2022
[Mechanisms by which acute orofacial pain becomes chronic]
1Programme d'Antalgie Interventionnelle, Service d'Anesthésiologie Département APSIC, Hôpitaux Universitaires de Genève, Suisse. alex.cahanacuge.ch
Revue De Stomatologie Et De Chirurgie Maxillo-Faciale
|June 29, 2006
Summary
Understanding orofacial pain involves sensory, emotional, and cognitive factors. This review explores neurobiology and bio-psycho-social interactions to improve diagnosis and treatment of temporomandibular disorders and other orofacial pain conditions.
Area of Science:
- Neuroscience
- Pain Research
- Orofacial Medicine
Context:
- Orofacial pain is a prevalent and complex condition.
- Syndromes like temporomandibular disorders (TMD) and burning mouth syndrome are common.
- Psychosocial factors significantly influence the persistence of orofacial pain.
Purpose:
- To review advances in understanding the neurobiology of orofacial pain.
- To explore peripheral and central nervous system mechanisms in nociceptive transmission.
- To link neurobiological insights to clinical management of acute and chronic orofacial pain.
Summary:
- Pain is a multidimensional experience with unique aspects in the orofacial region.
- Difficulties in diagnosing and managing orofacial pain arise from complex bio-psycho-social interactions and neurobiology.
- This review examines advances in peripheral processes, brainstem pathways, trigeminal system, and nociceptive plasticity.
Impact:
- Improved understanding of orofacial pain mechanisms.
- Enhanced diagnostic and therapeutic strategies for clinicians.
- Potential to prevent the chronicization of acute orofacial pain.
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