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Published on: May 4, 2021
Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue
Kun-yong Kim1, Hwa Young Kim, Jae Hyeong Kim
1Department of Life Science, Research Center for Women's Diseases, Sookmyung Women's University, Seoul 140-742, Republic of Korea.
FEBS Letters
|June 30, 2006
Summary
Cardiotrophin-like cytokine type 1 (CTRP1) expression increases in adipose tissue during inflammation. Tumor necrosis factor-alpha and interleukin-1beta mediate this response, suggesting CTRP1
Area of Science:
- Biochemistry and Molecular Biology
- Endocrinology
- Immunology
Background:
- CTRP1 is a member of the CTRP superfamily, characterized by specific structural domains.
- Adipose tissue plays a crucial role in metabolic and inflammatory processes.
- Chronic low-grade inflammation in adipose tissue is linked to metabolic dysfunction.
Purpose of the Study:
- To investigate the expression patterns of CTRP1 in adipose tissue under inflammatory conditions.
- To elucidate the molecular mechanisms regulating CTRP1 gene expression during inflammation.
- To explore the potential association of CTRP1 with adipose tissue inflammation.
Main Methods:
- Gene expression analysis of CTRP1 in adipose tissues of Sprague-Dawley rats stimulated with lipopolysaccharide (LPS).
- Investigation of the role of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in mediating LPS-induced CTRP1 expression.
- Comparison of CTRP1 mRNA levels in adipose tissues of Zucker diabetic fatty (fa/fa) rats and Sprague-Dawley rats.
Main Results:
- CTRP1 exhibits high expression levels in the adipose tissues of LPS-stimulated Sprague-Dawley rats.
- The increase in CTRP1 gene expression induced by LPS is mediated by TNF-alpha and IL-1beta.
- Elevated CTRP1 mRNA levels are observed in the adipose tissues of Zucker diabetic fatty rats compared to controls.
Conclusions:
- CTRP1 expression is significantly upregulated in adipose tissue during inflammatory states.
- Pro-inflammatory cytokines TNF-alpha and IL-1beta are key regulators of CTRP1 expression in adipose tissue.
- CTRP1 may serve as a biomarker or play a role in the low-grade chronic inflammation characteristic of adipose tissue.
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