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Updated: Aug 7, 2026
09:15
Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
Published on: May 7, 2019
[Renal transplantation with positive crossmatch]
A Sancho1, E Gavela, J F Crespo
1Servicio de Nefrología, Hospital Universitari Dr Peset, Valencia. asanchoc@senefro.org
Summary
Kidney transplants with positive crossmatches, despite high antibody levels, showed satisfactory graft survival. This indicates successful renal transplantation is achievable even with immunological challenges.
Area of Science:
- Nephrology
- Immunology
- Transplantation Science
Context:
- Positive crossmatches due to lymphocytotoxic antibodies pose a significant challenge in renal transplantation.
- High panel reactivity is common in patients requiring repeat kidney transplants.
Purpose:
- To evaluate the outcomes of kidney transplants performed with positive T and/or B lymphocyte crossmatches.
- To assess graft survival and function in recipients with pre-existing antibodies.
Summary:
- Eight kidney transplants were analyzed in the presence of positive historical crossmatches.
- Patients received quadruple therapy with thymoglobulin induction; six had good renal function post-transplant.
- One graft was lost to chronic allograft nephropathy, and one experienced primary non-function.
Impact:
- Renal transplantation is feasible and can achieve satisfactory graft survival even in highly sensitized patients.
- This study supports the consideration of transplantation for patients with positive crossmatches.
- Outcomes highlight the importance of effective immunosuppression protocols.
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