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Matrix metalloproteinases--a conceptional alternative for disease-modifying strategies in ALS/MND?

Albert C Ludolph1

  • 1Department of Neurology, University of Ulm, Oberer Eselsberg 45, Ulm, Germany. albert.ludolph@rku.de

Experimental Neurology
|July 1, 2006
PubMed
Abstract

No abstract available in PubMed .

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Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
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