Related Experiment Video
Updated: Aug 7, 2026

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
Published on: June 20, 2017
Post-traumatic amnesia predicts long-term cerebral atrophy in traumatic brain injury
Elisabeth A Wilde1, Erin D Bigler, Claudia Pedroza
1Baylor College of Medicine, Department of Physical Medicine and Rehabilitation, Houston, TX 77030, USA. ewilde@bcm.tmc.edu
Primary Objective:
To examine post-traumatic amnesia (PTA) and its relation to long-term cerebral atrophy in persons with traumatic brain injury (TBI) using objective indicators of PTA duration and Quantitative Magnetic Resonance Imaging (QMRI). It was hypothesized that longer PTA would predict later generalized atrophy (increased ventricle-to-brain ratio (VBR)). As a guide in assessing patients with TBI, this study determined the probability of developing chronic cerebral atrophy based on PTA duration.
Research Design:
Probability model using 60 adult patients with mild-to-severe TBI.
Main Outcomes And Results:
A logistic regression model with a cut-off determined by normative QMRI data confirmed that longer PTA duration predicts increased VBR. A probability model demonstrated a 6% increase in the odds of developing later atrophy on neuroimaging with each additional day of PTA.
Conclusions:
PTA has previously proven to be a good indicator of later cognitive recovery and functional outcome and also predicts long-term parenchymal change.
Related Concept Videos
Traumatic Brain Injury l: Introduction
Traumatic Memory
Amnesia
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
Higher Mental Functions of Brain: Learning and Memory

