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Published on: September 12, 2019
p16-Positive small cell neuroendocrine carcinoma of the endometrium
Frank Melgoza1, Wendy R Brewster, Sharon Wilczynski
1Department of Pathology, University of California Irvine Medical Center, Orange, California 92868, USA. fmelgoza@uci.edu
Abstract:
We report herein a small cell neuroendocrine carcinoma of the endometrium that extended to the cervix and showed strong immunohistochemical staining for p16. The p16 staining raised the possibility of a human papillomavirus (HPV)-related tumor, because in the cervix, a positive p16 immunohistochemical stain is presumptive evidence of HPV. However, the current case was HPV negative. We discuss the molecular pathogenesis of non-HPV-related increased p16 expression.