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Oral sumatriptan in acute migraine
P J Goadsby1, A S Zagami, G A Donnan
1Department of Neurology, Prince Henry, Australia.
Lancet (London, England)
|September 28, 1991
Summary
Oral sumatriptan effectively treats acute migraine attacks. This study found sumatriptan significantly reduced migraine severity compared to placebo, with minimal side effects.
Area of Science:
- Neurology
- Clinical Pharmacology
Background:
- Migraine is a common neurological disorder.
- Effective acute treatments are crucial for managing migraine attacks.
Purpose of the Study:
- To evaluate the efficacy and tolerability of oral sumatriptan for acute migraine.
- To compare sumatriptan's effectiveness against a placebo in a controlled setting.
Main Methods:
- A double-blind, randomized, placebo-controlled, crossover study.
- 61 patients with acute migraine were included.
- Patients received either sumatriptan 100 mg or placebo for four attacks.
Main Results:
- Sumatriptan showed a significantly higher response rate (51%) compared to placebo (10%) at 2 hours (p<0.01).
- Fewer patients required rescue medication with sumatriptan (41%) versus placebo (88%) at 2 hours.
- No significant side effects were reported.
Conclusions:
- Oral sumatriptan is an effective and well-tolerated treatment for acute migraine.
- Sumatriptan offers a valuable therapeutic option for migraineurs.
- Further research could explore long-term efficacy and recurrence patterns.
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