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Published on: July 15, 2013
Chemokine scavenging by D6: a movable feast?
Gerard J Graham1, Clive S McKimmie
1Division of Immunology, Infection and Inflammation, University of Glasgow, G12 8TA, UK. g.graham@clinmed.gla.ac.uk
Trends in Immunology
|July 4, 2006
Summary
The atypical chemokine receptor D6 (decoy receptor 6) efficiently clears inflammatory signals. This study suggests leukocytes, not just lymphatic cells, are key in resolving inflammation by scavenging these signals.
Area of Science:
- Immunology
- Cell Biology
- Inflammation Research
Background:
- Atypical chemokine receptor D6 (decoy receptor 6) scavenges inflammatory CC-chemokines.
- D6 deficiency impairs the resolution of inflammatory immune responses.
- Lymphatic endothelial cells are traditionally considered the primary mediators of D6 function in vivo.
Purpose of the Study:
- To investigate the role of leukocytes as potential primary vehicles for D6-mediated chemokine scavenging.
- To explore the distinct function of D6 expressed on lymphatic endothelial cells.
Main Methods:
- The study proposes a new model for D6 function.
- It involves analyzing chemokine scavenging by different cell types in inflammatory models.
Main Results:
- Leukocytes expressing D6 are proposed as more effective scavengers of inflammatory chemokines.
- Leukocytes may be the primary cell type responsible for removing chemokines from inflamed tissues.
- D6 on lymphatic endothelial cells may play a complementary role in regulating leukocyte trafficking.
Conclusions:
- Leukocytes are potentially the main cell type for D6-mediated chemokine scavenging during inflammation.
- D6 on lymphatic endothelial cells might regulate inflammatory leukocyte entry into lymphatic vessels.
