Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The DNA Helix

The DNA Helix

The DNA Helix

The DNA Helix

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

DNA-only Transposons

DNA-only Transposons

DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...

The DNA Helix

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Topological Regulatory Logic of noncoding RNA-mediated gene expression.

Genome research·2026

Same author

Author Correction: MaizeCODE reveals bi-directionally expressed enhancers that harbor molecular signatures of maize domestication.

Nature communications·2025

Same author

MaizeCODE reveals bi-directionally expressed enhancers that harbor molecular signatures of maize domestication.

Nature communications·2024

Same author

The EN-TEx resource of multi-tissue personal epigenomes & variant-impact models.

Cell·2023

Same author

Long non-coding RNAs: definitions, functions, challenges and recommendations.

Nature reviews. Molecular cell biology·2023

Same author

Author Correction: Expanded encyclopaedias of DNA elements in the human and mouse genomes.

Nature·2022

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

TUF love for "junk" DNA.

Aarron T Willingham¹, Thomas R Gingeras

¹Affymetrix, Inc., Santa Clara, CA 95051, USA.

|July 4, 2006

Summary

Noncoding RNAs (ncRNAs) are abundant in eukaryotes and play crucial roles in genome organization and regulation. Research into these functional transcripts is vital for understanding complex genomic processes.

Area of Science:

Genomics
Molecular Biology
Bioinformatics

Background:

Eukaryotic genomes contain a vast number of transcripts.
Many of these transcripts lack protein-coding potential, traditionally termed noncoding RNAs (ncRNAs).
The functional significance of ncRNAs has been historically underestimated.

Observation:

Noncoding RNAs are widespread across eukaryotic organisms.
These ncRNAs exhibit reduced protein-coding capacity.
Their prevalence suggests inherent biological importance.

Findings:

The study of ncRNAs is rapidly expanding.
ncRNAs are key players in the intricate organization of genomes.
ncRNAs are increasingly recognized for their roles in genome regulation.

More Related Videos

Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue

Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue

Published on: May 9, 2019

Extraction of Diatom DNA from Water Samples and Tissues

Extraction of Diatom DNA from Water Samples and Tissues

Published on: November 10, 2023

Related Experiment Videos

Last Updated: Jun 30, 2026

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue

Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue

Published on: May 9, 2019

Extraction of Diatom DNA from Water Samples and Tissues

Extraction of Diatom DNA from Water Samples and Tissues

Published on: November 10, 2023

Implications:

Understanding ncRNAs is crucial for deciphering genome complexity.
Further research into ncRNAs will illuminate novel regulatory mechanisms.
This field holds potential for future genomic and therapeutic applications.