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Attenuation of hippocampal inhibition by a NMDA (N-methyl-D-aspartate) receptor antagonist
1Department of Pharmacology and Therapeutics, McGill University, Montreal, Que., Canada.
Neuroscience Letters
|August 5, 1991
Abstract:
The effects of the competitive NMDA (N-methyl-D-aspartate) receptor antagonist, APV (2-amino-5-phosphonopentanoate; AP5), were examined in the hippocampal slice preparation. APV (50-100 microM) attenuated inhibition of the orthodromically evoked population spikes in the CA1 region produced by a conditioning stimulus to the alveus or to the stratum radiatum. This suggests that NMDA receptors contribute to synaptic activation of the inhibitory interneurons by a single afferent volley.