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Postoperative radiation therapy for T1 and T2 primary parotid carcinoma: is it useful?
Peter Zbären1, Michel Nuyens, Marco Caversaccio
1Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, CH-3000 Berne, Switzerland. peter.zbaeren@insel.ch
Objective:
The benefit of postoperative radiation for advanced primary parotid carcinoma has been reported previously, whereas studies to evaluate the usefulness of postoperative radiation for T1 and T2 parotid carcinomas have never been performed.
Study Design And Setting:
Retrospective analysis on 58 previously untreated patients with T1 and T2 parotid carcinomas. In 34 patients, postoperative radiation was included in the treatment protocol and in 24 patients, no postoperative radiation was applied.
Results:
A local recurrence was observed in 8 of 24 (33%) patients without and in 1 of 34 (3%) patients with postoperative radiation (P < 0.5). The 5-year actuarial and disease-free survival rate was 83% and 70% for patients without postoperative radiation and 93% and 92% for patients with postoperative radiation.
Conclusion And Significance:
Local recurrence was less often observed in patients with postoperative radiation. Nevertheless, prospective randomized studies are needed to confirm the usefulness of postoperative radiation in early carcinomas.
Ebm Rating:
B-3b.