Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rustling synaptic vesicle cargo after exocytosis.

Chad Grabner1, David Zenisek

  • 1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA.

Neuron
|July 4, 2006
PubMed
Summary

Synaptic vesicle transporters are retrieved to the cell surface via at least two distinct endocytic pathways after exocytosis. This study reveals new mechanisms for sorting synaptic vesicle cargo.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Germ layer-specific interaction of ion channels and transporters controls membrane potential and left-right patterning in Xenopus tropicalis.

Communications biology·2026
Same author

Distinct Roles of CaMKII in Synaptic Vesicle Dynamics at Zebrafish Retinal Rod Bipolar Ribbon Synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Nanophysiology approach reveals diversity in calcium microdomains across zebrafish retinal bipolar ribbon synapses

eLife·2025
Same author

Electrophysiological profiling of exocytosis during early-stage development of the zebrafish lateral line.

bioRxiv : the preprint server for biology·2025
Same author

Distinct Roles of CaMKII in Synaptic Vesicle Dynamics at Zebrafish Retinal Rod Bipolar Ribbon Synapses.

bioRxiv : the preprint server for biology·2025
Same author

TMBIM4 affects left-right patterning via pluripotency exit during gastrulation.

Developmental biology·2025

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Synaptic transmission relies on the recycling of synaptic vesicles.
  • The retrieval and sorting of synaptic vesicle components after exocytosis are critical for neuronal function.

Discussion:

  • Voglmaier et al. demonstrate that synaptic vesicle transporters utilize multiple endocytic routes for surface retrieval.
  • This finding challenges previous models suggesting a single endocytic pathway for transporter recycling.

Key Insights:

  • At least two distinct endocytic pathways are involved in synaptic vesicle transporter retrieval post-exocytosis.
  • The study elucidates novel mechanisms for the sorting of synaptic vesicle cargo at the plasma membrane.

Outlook:

  • Further research can explore the molecular machinery distinguishing these pathways.
  • Understanding these mechanisms could offer insights into neurological disorders associated with impaired synaptic vesicle trafficking.

Related Experiment Videos