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Updated: Jul 6, 2026

Isolating Lymphocytes from the Mouse Small Intestinal Immune System
Published on: February 28, 2018
Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones
P Salgame1, J S Abrams, C Clayberger
1Howard Hughes Medical Institute, Albert Einstein College of Medicine, New York, NY 10461.
Abstract:
Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-gamma, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-gamma. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.
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