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Dendritic spikes and activity-dependent synaptic plasticity.

Knut Holthoff1, Yury Kovalchuk, Arthur Konnerth

  • 1Institute of Neuroscience, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany. knut.holthoff@lrz.tu-muenchen.de

Cell and Tissue Research
|July 4, 2006
PubMed
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Neuronal dendrites are not passive; they exhibit active conductances and generate regenerative responses like dendritic spikes. This dendritic activity is crucial for neuronal information processing and synaptic plasticity.

Area of Science:

  • Neuroscience
  • Cellular Neuroscience
  • Computational Neuroscience

Background:

  • Historically, neuronal dendrites were viewed as passive structures transmitting synaptic inputs.
  • Recent discoveries reveal active conductances within dendrites, challenging this passive model.
  • These active properties significantly alter our understanding of neuronal information processing.

Purpose of the Study:

  • To review experimental and theoretical evidence for regenerative dendritic activity.
  • To highlight the role of dendritic spikes in neuronal computation.
  • To explore the impact of dendritic activity on synaptic plasticity.

Main Methods:

  • Review of recent experimental findings on dendritic excitability.
  • Analysis of theoretical models of dendritic information processing.

Related Experiment Videos

  • Synthesis of evidence linking dendritic spikes to synaptic plasticity.

    • Main Results:

    • Dendrites possess active conductances, enabling regenerative responses.
    • Action potentials can actively back-propagate into dendrites.
    • Dendrites can generate intrinsic regenerative events, termed dendritic spikes.

    Conclusions:

    • Regenerative dendritic activity plays a vital role in neuronal information processing.
    • Dendritic spikes are key mechanisms underlying activity-dependent synaptic plasticity.
    • Active dendritic properties are fundamental to understanding neural computation.