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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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Genetic background controls tumor development in PTEN-deficient mice

Dan Freeman1, Ralf Lesche, Nathalie Kertesz

  • 1Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, 650 C.E. Young Drive South, Los Angeles, CA 90095, USA.

Cancer Research
|July 5, 2006
PubMed
Summary

Genetic background significantly impacts cancer development in Pten mutation mouse models. Tumor formation and progression depend more on the genetic environment than the specific Pten gene mutation.

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