ZooDDD: a cross-species database for digital differential display analysis
Yun-Ching Chen1, Chung-Der Hsiao, Wen-Dar Lin
1Institute of Information Science, Academia Sinica, NanKang 115, Taipei, Taiwan, Republic of China.
Bioinformatics (Oxford, England)
|July 6, 2006
Summary
Researchers developed the ZooDDD database to identify evolutionary conserved, highly expressed, and tissue-specific genes in model animals. This resource aids in comparing animal genome expression, function, and evolution.
Area of Science:
- Genomics
- Comparative Genomics
- Bioinformatics
Background:
- UniGene and Ensembl databases provide essential genetic and orthology information.
- Model animals are crucial for understanding broader evolutionary and functional genomic principles.
Purpose of the Study:
- To construct the ZooDDD database for identifying specific types of genes.
- To facilitate comparative analysis of animal genomes.
Main Methods:
- Combined expressed sequence tag (EST) data from UniGene.
- Integrated orthologous relationships from Ensembl.
- Developed the ZooDDD database to mine specific gene sets.
Main Results:
- Successfully constructed the ZooDDD database.
- Enabled mining of evolutionary conserved, highly expressed, tissue-specific orthologues.
- Provided a resource for candidate gene identification.
Conclusions:
- The ZooDDD database is a valuable tool for biologists.
- Facilitates comparative studies of gene expression, function, and evolution across animal genomes.
