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Multiple endocrine neoplasia type III.

M A Nasir1, R W Yee, K L Piest

  • 1Department of Ophthalmology, University of Texas Health Science Center, San Antonio.

Cornea
|September 1, 1991
PubMed
Summary
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Multiple endocrine neoplasia (MEN) syndromes are inherited disorders affecting multiple endocrine glands. Ophthalmologic findings in MEN type III can lead to early diagnosis, preventing life-threatening conditions.

Area of Science:

  • Endocrinology
  • Genetics
  • Ophthalmology

Background:

  • Multiple endocrine neoplasia (MEN) syndromes are inherited disorders characterized by hyperplastic or neoplastic changes in endocrine tissues.
  • Syndromes are classified based on the affected endocrine glands, including MEN type I, MEN type II/IIA, and MEN type III/IIB.

Observation:

  • MEN type III presents with a marfanoid habitus, mucosal neuromas, and specific ophthalmologic findings.
  • Ophthalmologic signs include prominent corneal nerves, thickened eyelids, and subconjunctival neuromas.

Findings:

  • Ocular examination can reveal characteristic features of MEN type III.
  • These distinct ocular manifestations aid in early syndrome identification.

Implications:

Related Experiment Videos

  • Early diagnosis of MEN type III through ophthalmologic findings is crucial.
  • Prompt diagnosis allows for intervention before the development of severe conditions like medullary thyroid carcinoma and pheochromocytoma.