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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Related Experiment Video

Updated: Jul 3, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Osimertinib-Associated Benign Ocular Hyperpigmentation: A Case Report.

Nuhansi Wijesinghe1, Jennifer Chin2,3, Ann Chung4,5

  • 1Monash University, Melbourne, Australia.

Cornea
|July 1, 2026
PubMed
Summary
This summary is machine-generated.

Long-term use of osimertinib may cause benign hyperpigmentation of the conjunctiva and cornea. This finding is important to distinguish from primary acquired melanosis, a condition that can progress to melanoma.

Keywords:
EGFR-TKIbenign ocular hyperpigmentationcase reportconjunctival hyperpigmentationosimertinibpigmented vortex keratopathy

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pharmacology

Background:

  • Osimertinib is a targeted therapy for non-small-cell lung cancer.
  • Ocular side effects of targeted cancer therapies require careful monitoring.

Purpose of the Study:

  • To describe a case of conjunctival and corneal epithelial hyperpigmentation.
  • To highlight the association with long-term osimertinib treatment.

Main Methods:

  • Observational case report.
  • Clinical examination of ocular findings.

Main Results:

  • Bilateral benign hyperpigmentation of the conjunctiva and corneal epithelium was observed.
  • Pigmentation involved the caruncle and lid margins.
  • The patient had a history of non-small-cell lung cancer treated with osimertinib for 4 years.

Conclusions:

  • Osimertinib use can lead to rare, benign ocular hyperpigmentation.
  • Differentiating this from primary acquired melanosis is crucial due to melanoma risk.