Related Experiment Video
Updated: Aug 7, 2026

Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects
Published on: June 30, 2017
Photothermally induced delayed tissue death
Jeffrey M Gordon1, Ruthy Shaco-Levy, Daniel Feuermann
1Ben-Gurion University of the Negev, Jacob Blaustein Institutes for Desert Research, Department of Solar Energy & Environmental Physics, Sede Boqer Campus, Israel. jeff@bgu.ac.il
Abstract:
We report pronounced delayed tissue death in photothermal surgery performed on the livers of live healthy rats with highly concentrated sunlight (ultrabright noncoherent light). Exposure times and power levels were selected to produce immediate necroses of the order of hundreds of cubic millimeters. Pathology reveals that lesion volumes increase by up to a factor of 5 within approximately 24 h after surgery, and then stabilize. Islands of viable cells can persist within damaged tissue, in the immediate vicinity of blood vessels, but also necrose within about 48 h.
Related Concept Videos
Physical Methods for Controlling Microbial Growth: Temperature
Cellular Injury IV: Necrosis
Cellular Injury IlI: Cellular Death
Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
