Jove
Visualize
Contact Us

Related Concept Videos

Histology of the Uterus01:19

Histology of the Uterus

1.3K
The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
The endometrium is the...
1.3K
Metastasis02:30

Metastasis

5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. The Significance Of Lower Uterine Segment Involvement In Endometrial Cancer.
  1. Home
  3. The Significance Of Lower Uterine Segment Involvement In Endometrial Cancer.

Related Experiment Video

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

11.4K

The significance of lower uterine segment involvement in endometrial cancer.

Sharon Davidesko1, Mihai Meirovitz1, Ruthy Shaco-Levy2

  • 1Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Department of Gynecological Oncology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|February 21, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Lower uterine segment involvement (LUSI) in endometrial cancer is linked to poorer outcomes, including shorter progression-free survival (PFS) and overall survival (OS). This finding suggests LUSI may warrant consideration for adjuvant treatment decisions.

Keywords:
Endometrial adenocarcinomaLower uterine segmentOverall survivalPrognostic factorsProgression-free survival

More Related Videos

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
07:44

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Published on: February 17, 2023

1.5K
An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

8.1K

Related Experiment Videos

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
05:52

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

11.4K
Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice
07:44

Non-Invasive Ultrasound Assessment of Endometrial Cancer Progression in Pax8-Directed Deletion of the Tumor Suppressors Arid1a and Pten in Mice

Published on: February 17, 2023

1.5K
An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

8.1K

Area of Science:

  • Gynecologic Oncology
  • Pathology
  • Cancer Prognostics

Background:

  • Limited data suggests lower uterine segment involvement (LUSI) in endometrial cancer may correlate with adverse prognostic factors.
  • The precise impact of LUSI on endometrial cancer prognosis remains unclear.

Purpose of the Study:

  • To investigate the association between lower uterine segment involvement (LUSI) and prognosis in endometrial cancer patients.
  • To determine if LUSI is an independent prognostic indicator for overall survival (OS) and progression-free survival (PFS).

Main Methods:

  • Pathological samples from 429 endometrial cancer patients (2002-2022) were revised.
  • Clinical data and outcomes were analyzed comparing patients with and without LUSI.
  • Kaplan-Meier survival analysis was used to compare OS and PFS.

Main Results:

  • 45 patients (10.5%) exhibited LUSI, with no significant demographic differences.
  • LUSI was significantly associated with lympho-vascular space invasion and lymph node involvement.
  • Patients with LUSI showed significantly shorter PFS and OS, though multivariate analysis was not significant.

Conclusions:

  • Lower uterine segment involvement (LUSI) may indicate a poorer prognosis in endometrial cancer.
  • LUSI could be a factor in adjuvant treatment decisions, particularly for endometrioid-type and early-stage endometrial cancer.