The significance of lower uterine segment involvement in endometrial cancer

Area of Science:

• Gynecologic Oncology
• Pathology
• Cancer Prognostics

Background:

• Limited data suggests lower uterine segment involvement (LUSI) in endometrial cancer may correlate with adverse prognostic factors.
• The precise impact of LUSI on endometrial cancer prognosis remains unclear.

Purpose of the Study:

• To investigate the association between lower uterine segment involvement (LUSI) and prognosis in endometrial cancer patients.
• To determine if LUSI is an independent prognostic indicator for overall survival (OS) and progression-free survival (PFS).

Main Methods:

• Pathological samples from 429 endometrial cancer patients (2002-2022) were revised.
• Clinical data and outcomes were analyzed comparing patients with and without LUSI.
• Kaplan-Meier survival analysis was used to compare OS and PFS.

Main Results:

• 45 patients (10.5%) exhibited LUSI, with no significant demographic differences.
• LUSI was significantly associated with lympho-vascular space invasion and lymph node involvement.
• Patients with LUSI showed significantly shorter PFS and OS, though multivariate analysis was not significant.

Conclusions:

• Lower uterine segment involvement (LUSI) may indicate a poorer prognosis in endometrial cancer.
• LUSI could be a factor in adjuvant treatment decisions, particularly for endometrioid-type and early-stage endometrial cancer.