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Related Experiment Videos

Antioxidant down-regulates interleukin-18 expression in asthma.

Kyung Sun Lee1, So Ri Kim, Seoung Ju Park

  • 1Department of Internal Medicine, Chonbuk National University Medical School, San 2-20, Geumamdong, Deokjin-gu, Jeonju, Jeonbuk 561-180, South Korea.

Molecular Pharmacology
|July 11, 2006
PubMed
Summary

Antioxidants like L-2-oxothiazolidine-4-carboxylic acid and alpha-lipoic acid can reduce airway inflammation and bronchial hyperresponsiveness in asthma models. They achieve this by decreasing reactive oxygen species (ROS) and interleukin-18 (IL-18) expression, potentially by inhibiting nuclear factor-kappaB (NF-kappaB) activity.

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Area of Science:

  • Immunology
  • Respiratory Medicine
  • Oxidative Stress Research

Background:

  • An imbalance between T-helper type 1 (Th1) and T-helper type 2 (Th2) responses is linked to bronchial asthma.
  • Interleukin-18 (IL-18) influences both Th1 and Th2 responses, and reactive oxygen species (ROS) are implicated in airway inflammation and hyperresponsiveness.

Purpose of the Study:

  • To investigate the impact of antioxidants on the regulation of IL-18 expression in a murine model of allergic asthma.
  • To explore the role of ROS in controlling IL-18 expression within the context of asthma.

Main Methods:

  • Utilized a C57BL/6 mouse model of ovalbumin-induced allergic asthma.
  • Administered antioxidants L-2-oxothiazolidine-4-carboxylic acid or alpha-lipoic acid.
  • Measured ROS production, IL-18 protein and mRNA expression, airway inflammation, bronchial hyperresponsiveness, and nuclear factor-kappaB (NF-kappaB) activity.

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Main Results:

  • Increased ROS production was observed in bronchoalveolar lavage fluid cells from asthmatic mice.
  • Antioxidant treatment significantly reduced ROS levels, IL-18 expression, airway inflammation, and bronchial hyperresponsiveness.
  • Antioxidants were found to down-regulate the activity of the transcription factor NF-kappaB.

Conclusions:

  • Antioxidants may mitigate IL-18 expression in asthma by suppressing NF-kappaB activity.
  • ROS play a regulatory role in controlling IL-18 expression in the context of asthma.
  • Antioxidant interventions show potential for managing asthma by targeting ROS and IL-18 pathways.