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  3. Exploring Cough Hypersensitivity Patterns Across Respiratory Diseases.
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  3. Exploring Cough Hypersensitivity Patterns Across Respiratory Diseases.

Related Experiment Video

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

Exploring cough hypersensitivity patterns across respiratory diseases.

Hyeon-Kyoung Koo1, Tai Joon An2, Hyonsoo Joo3

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.

Respiratory Medicine
|June 20, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

The Cough Hypersensitivity Questionnaire (CHQ) reveals distinct aspects of chronic cough hypersensitivity not captured by standard measures. It shows varied triggers and sensations across different respiratory diseases, aiding in a multidimensional understanding of cough.

Keywords:
Chronic coughCough hypersensitivityCough hypersensitivity questionnaireNetwork analysisStructural lung diseaseSymptom patterns

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Machine Learning-Based Cough Tone Classification: Diagnostic Exploration of Chronic Obstructive Pulmonary Disease and Respiratory Tract Infections

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Area of Science:

  • Respiratory Medicine
  • Clinical Psychology

Background:

  • Cough hypersensitivity is a key mechanism in chronic cough.
  • The Cough Hypersensitivity Questionnaire (CHQ) assesses triggers and sensory perceptions.
  • The CHQ's relevance across respiratory diseases needs clarification.

Purpose of the Study:

  • To evaluate the structural and clinical relevance of the CHQ across diverse respiratory diseases.
  • To assess associations between CHQ items and other cough measures.

Main Methods:

  • Prospective enrollment of 300 adults with chronic cough.
  • Completion of four questionnaires: NRS, LCQ, COAT, and CHQ.
  • Spearman correlation and network analyses, including disease-specific subgroup analyses.

Main Results:

  • CHQ showed variable associations with conventional instruments and differing patterns across diseases.
  • Specific triggers correlated with hypersensitivity and social interference items.
  • No significant association between CHQ and NRS indicated dissociation from perceived severity.
  • Broader associations observed in asthma and bronchiectasis compared to COPD and IPF.

Conclusions:

  • The CHQ captures unique dimensions of cough hypersensitivity.
  • These dimensions are not fully reflected by conventional cough measures.
  • The CHQ may help characterize multidimensional aspects of chronic cough.