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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Hemorrhagic complications after endovascular therapy for atherosclerotic intracranial arterial stenoses
Tomoaki Terada1, Mitsuharu Tsuura, Hiroyuki Matsumoto
1Department of Neurological Surgery, Wakayama Medical University, Wakayama City, Japan. teradato@wakayama-med.ac.jp
Insights
Hemorrhagic complications occurred in 3% of intracranial angioplasty or stenting procedures. Hyperperfusion syndrome was a likely cause in 2% of cases, highlighting risks of revascularization treatments.
Area of Science:
- Neurology
- Interventional Neuroradiology
- Vascular Surgery
Background:
- Intracranial arterial stenoses pose a risk for stroke.
- Percutaneous transluminal angioplasty (PTA) and stenting are treatment options.
- Hemorrhagic complications are a potential adverse event.
Observation:
- A study analyzed 106 procedures (99 patients) for intracranial arterial stenosis.
- Hemorrhagic complications occurred in 4 procedures (3%).
- Causes included intracerebral hemorrhage, subarachnoid hemorrhage, and hemorrhagic infarction.
Findings:
- Two cases of intracerebral hemorrhage were linked to hyperperfusion syndrome.
- Hemodynamic compromise was identified in three patients with hemorrhage.
- Hemorrhagic infarction occurred after recanalization of stent thrombosis.
Implications:
- PTA and stenting for intracranial stenosis carry a procedural hemorrhagic risk.
- Hyperperfusion syndrome is a significant concern post-revascularization.
- Careful patient selection and monitoring are crucial to mitigate risks.
Objective:
Hemorrhagic complications were analyzed in 106 procedures of 99 patients treated with percutaneous transluminal angioplasty (PTA) or stenting for intracranial arterial stenoses.
Methods:
Ninety-nine patients with intracranial arterial stenosis were treated with PTA or stenting 106 times from January 1995 to December 2003. Fifty-seven patients had intracranial internal carotid artery stenosis, 23 had middle cerebral artery stenosis, and 19 had vertebrobasilar stenosis. Evaluation of hemodynamic compromise via single-photon emission computed tomography was performed 50 times for 50 patients before the treatment.
Results:
Four hemorrhagic complications occurred in 106 procedures. Two of these cases involved intracerebral hemorrhage after PTA or stenting in the treated vascular territory 30 minutes and 16 hours after the treatment, respectively. One case showed subarachnoid hemorrhage, which appeared 6 hours after treatment. Hemodynamic compromise was found on single-photon emission computed tomography in these three cases. The last case with a hemorrhagic complication was a hemorrhagic infarction after recanalization of stent thrombosis, which appeared 3 days after stenting. Hyperperfusion syndrome was strongly suggested as the cause of hemorrhage in the two cases associated with intracerebral hemorrhage.
Conclusion:
The rate of hemorrhagic complication directly related to the procedure of PTA or stenting was 3%, and hyperperfusion syndrome was suggested as the cause of hemorrhage in two cases (2%), from the perspective of clinical characteristics and single-photon emission computed tomographic findings.
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