Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

What mouse mutants teach us about extracellular matrix function.

A Aszódi1, Kyle R Legate, I Nakchbandi

  • 1Department of Molecular Medicine, Max Planck Institute for Biochemistry, 82152 Martinsried, Germany. aszodi@biochem.mpg.de

Annual Review of Cell and Developmental Biology
|July 11, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PIP5KIγ90-generated phosphatidylinositol-4,5-bisphosphate promotes the uptake of Staphylococcus aureus by host cells.

Molecular microbiology·2021
Same author

The Matrilin-3 T298M mutation predisposes for post-traumatic osteoarthritis in a knock-in mouse model.

Osteoarthritis and cartilage·2020
Same author

Fiberoptic microindentation technique for early osteoarthritis diagnosis: an in vitro study on human cartilage.

Biomedical microdevices·2019
Same author

Histological comparison of arterial thrombi in mice and men and the influence of Cl-amidine on thrombus formation.

PloS one·2018
Same author

[Isolation and Characterization of Multipotent Precursor Cells from Murine Adipose Tissue using a Clinically Approved Cell Separation System].

Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V...·2016
Same author

Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo.

Circulation research·2015
Same journal

Hidden Messages in Extracellular Vesicles: Cross-Kingdom RNA Communication in Plant and Microbe Interactions.

Annual review of cell and developmental biology·2026
Same journal

mRNA-Scaffolded Cytoplasmic Compartments.

Annual review of cell and developmental biology·2026
Same journal

Developmental Programming of Human Kidney Function.

Annual review of cell and developmental biology·2026
Same journal

The Translation of Genetic Information in Neurodevelopment.

Annual review of cell and developmental biology·2026
Same journal

The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles.

Annual review of cell and developmental biology·2026
Same journal

Interstitial Spaces: A Basolateral Source of Structure and Signals.

Annual review of cell and developmental biology·2026
See all related articles

The extracellular matrix, once seen as a simple scaffold, is now understood as a dynamic regulator of cell behavior. Genetic mouse models reveal its crucial roles in development, regeneration, and human diseases.

Area of Science:

  • Biochemistry
  • Developmental Biology
  • Genetics

Background:

  • Extracellular matrix (ECM) traditionally viewed as a passive scaffold.
  • Emerging evidence highlights ECM's active role in cellular behavior and tissue dynamics.
  • Genetic studies in mice are crucial for understanding ECM functions.

Purpose of the Study:

  • To review phenotypes of genetic mouse models with mutations in ECM proteins.
  • To emphasize recent advancements in understanding ECM's structural and instructive roles.
  • To explore the implications for human pathologies.

Main Methods:

  • Analysis of gene targeting, transgene expression, and spontaneous mutations in mice.
  • Review of phenotypes associated with genetic alterations in ECM proteins.

Related Experiment Videos

  • Application of reverse genetics to study ECM protein multifunctionality.

    • Main Results:

    • Genetic mouse models demonstrate ECM's critical involvement in development and regeneration.
    • Mutations in ECM proteins lead to diverse and significant phenotypic changes.
    • Reverse genetics provides novel insights into ECM's biological context and functions.

    Conclusions:

    • The extracellular matrix is a dynamic regulator of cellular functions.
    • Genetic mouse models are invaluable tools for dissecting ECM roles.
    • Understanding ECM dysfunction through genetic models offers new perspectives on human diseases.