Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developing and maintaining protective CD8+ memory T cells.

Matthew A Williams1, Brittany J Holmes, Joseph C Sun

  • 1Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Immunological Reviews
|July 11, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same author

Interleukin-12 induces rapid STAT4/DDX5-dependent remodeling of RNA polymerase II occupancy in NK cells.

The Journal of experimental medicine·2026
Same author

Ets1 represses Blimp1 to promote germinal center T follicular helper cell differentiation during viral infection.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Molecular determinants of NK cell memory.

Trends in immunology·2026
Same author

TOX drives CD4<sup>+</sup> T<sub>H</sub>1 effector function, antitumor immunity and autoimmune pathology.

Nature immunology·2026
Same author

Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes.

Immunity·2026
Same journal

Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire.

Immunological reviews·2026
Same journal

Macrophage Plasticity and Immune Remodeling in Ischemic Heart Failure.

Immunological reviews·2026
Same journal

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.

Immunological reviews·2026
Same journal

Tissue-Resident Memory T Cells in the Heart: An Emerging Role in Chronic Inflammation.

Immunological reviews·2026
Same journal

Rethinking Immunity in Tissues: The Biology of Tertiary Lymphoid Structures.

Immunological reviews·2026
Same journal

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity.

Immunological reviews·2026
See all related articles

CD4+ T cells are crucial for maintaining CD8+ memory T cells long-term, independent of CD40 signaling. They help CD8+ memory cells respond to IL-7 and IL-15, impacting vaccine efficacy.

Area of Science:

  • Immunology
  • Vaccinology
  • Cellular Biology

Background:

  • Understanding T cell memory is vital for effective vaccine development.
  • Long-term maintenance of functional memory T cells is a key goal in immunology.
  • CD8+ cytotoxic T lymphocytes (CTLs) are critical for adaptive immunity and pathogen clearance.

Purpose of the Study:

  • To investigate factors maintaining CD8+ memory T cells.
  • To identify early infection signals driving CD8+ memory T cell differentiation.
  • To elucidate the role of CD4+ T cells in CD8+ memory T cell generation and maintenance.

Main Methods:

  • Experimental design focused on two key questions regarding CD8+ memory T cell maintenance and differentiation.
  • Investigated the role of CD4+ T cells in CD8+ T cell-mediated protection and memory.

Related Experiment Videos

  • Manipulated infection time course and antigen presentation timing to CD8+ T cells.

    • Main Results:

    • CD4+ T cells are essential for CD8+ T cell-mediated protection against secondary infections.
    • CD4+ T cells are required for the long-term maintenance of CD8+ memory T cell numbers and function.
    • This CD4+ T cell function is independent of CD40-CD40L interactions.
    • CD4+ T cells may maintain CD8+ memory T cell responsiveness to IL-7 and IL-15.
    • Effector and memory potential programming are at least partially distinct processes.

    Conclusions:

    • CD4+ T cells play a dual role in CD8+ T cell memory: generation and long-term maintenance.
    • The mechanism of CD4+ T cell-mediated CD8+ memory maintenance involves supporting responses to cytokines like IL-7 and IL-15.
    • Distinct early-stage signals program effector versus memory T cell fates.