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Epidemiological study of constipation and other gastrointestinal symptoms in 8000 children
1Paediatric Department, Orebro University Hospital, Sweden. jonasludvigsson@yahoo.com
Insights
Childhood gastrointestinal issues like constipation are linked to socioeconomic status and infant sex. Parental smoking during pregnancy also affects infant gut health, increasing risks for various symptoms.
Area of Science:
- Pediatric Gastroenterology
- Public Health
- Epidemiology
Background:
- Gastrointestinal (GI) symptoms in children can be influenced by various factors.
- Previous adult studies suggest variations in GI symptoms based on sex and socioeconomic status.
- Understanding these associations in early childhood is crucial for identifying at-risk populations.
Purpose of the Study:
- To investigate the relationship between socioeconomic factors, infant sex, and parental smoking with the prevalence of GI symptoms in 2.5-year-old children.
- Specifically examining constipation, diarrhea, anorexia, abdominal pain, meteorism, and vomiting.
- To identify potential risk factors for pediatric GI disturbances.
Main Methods:
- Prospective cohort study (ABIS study) of children born between 01.10.97 and 01.10.99.
- Data collected via questionnaires at birth, 1 year, and 2.5 years of age.
- Logistic regression analysis used to assess associations between socioeconomic factors, infant sex, smoking, and GI symptoms.
Main Results:
- Constipation affected 6.5% of children and was associated with low maternal education, female sex, living in larger communities, and having no older siblings.
- Maternal smoking during pregnancy correlated with increased risk of diarrhea, anorexia, and meteorism.
- Paracetamol use was significantly linked to a higher risk of anorexia.
Conclusions:
- Socioeconomic status, infant sex, and parental smoking are significant factors associated with the development of gastrointestinal symptoms in young children.
- These findings highlight the importance of considering social and environmental determinants in pediatric GI health.
- Further research can explore targeted interventions based on identified risk factors.
Aim:
Adult studies indicate that gastrointestinal symptoms vary with sex and socioeconomic status. We examined socioeconomic factors, infant sex, smoking and gastrointestinal symptoms, especially constipation, in 2.5 year-old children.
Methods:
This study was part of a prospective cohort study of children born 01.10.97-01.10.99 (the ABIS study; All Babies in Southeast Sweden). Socioeconomic factors, infant sex, smoking were analyzed vs. constipation, diarrhoea, anorexia, abdominal pain, meteorism and vomiting using logistic regression. All data were obtained through questionnaires distributed at infant birth, at 1 and 2.5 years of age.
Results:
Out of 8341 children, 539 (6.5%) suffered from constipation. In a backward stepwise regression analysis (AOR; and 95% CI AOR = are given within brackets), constipation correlated with low maternal education (1.60; 1.08-2.35), female sex (1.52; 1.23-1.85), living in a large community with >3000 inhabitants (1.35; 1.09-1.64) and having no older siblings (1.28; 1.04-1.59). Smoking during pregnancy was linked to diarrhoea (multivariate analysis: 1.76; 1.02-3.02), anorexia (univariate analysis: 1.43; 1.09-1.87) and meteorism (univariate analysis: 1.58; 1.11-2.27). Adjusting for confounders, paracetamol use was linked to a five-fold increased risk of anorexia (5.12; 1.26-20.70).
Conclusions:
This study indicates that socioeconomic status, infant sex and parental smoking, are associated with gastrointestinal symptoms in children.
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